A study comparing children and adults with Treacher Collins syndrome have reported that adults suffer from:
higher level of depression
lower quality of life
Lower well-being,
Lower physical health-related quality of life.
The experience of patients with Treacher Collins syndrome having to interact with their society lead to, according to multiple reports, the feeling of isolation due to their facial appearance.
This has negative feedback as it can lead to lack of socialization and avoidance of social environment.