Treacher-Collins Syndrome
Treacher-Collins Syndrome, also known as mandibulofacial dysostosis, is a genetic, skeletal and soft tissue condition caused by the mutation in the gene TCOF1. It leads to the failure of migration of neural crest cells in the face leading to several oral, facial, auditory, and respiratory defects. The diagnosis of TCS is ideally made in the prenatal stage (2nd trimester) by 2D or 3D detective radiographs. Those with Treacher Collins syndrome present with occlusal and skeletal disharmony varying in the degree of phenotypes. Consequently, causing malfunctions of organs such as respiratory tube, auditory tube, and the mandible. Treatment of TCS patients follow a multidisciplinary approach, comprising of surgical and conservative treatment plans from the birth till adulthood.
